This chapter discusses the conceptual connection between habit formation and Self-Organization, taking Peirce’s philosophy as its conceptual ground, specifically his genetic ontology. By genetic it means a set of hypotheses intended to explain the origin of all phenomena, and by ontology, the set of hypotheses about the reality of such phenomena. Peirce proposes a monistic approach, which not only ruptures with all genetic dualism but also semiotically extends the properties of the human mind to all natural phenomena. Based on these ideas, we argue that it is feasible to think of the phenomena of habit formation in every cosmic being, and of Self-Organization as the building of mediations to successfully guide actions to any deliberated ends. Both ideas are connected under the monistic hypothesis of a genetic tendency of the mind.