The therapeutic relationship is a human-to-human interaction that usually takes place between a client and a caregiver in or outside of a health setting, aimed at helping the client in recovery. Models of recovery among clients who have mental health challenges encourage the development of resiliency and autonomy, even in the presence of symptoms; however, clients must be active participants in their care to achieve such aims. The quality of the therapeutic relationship is a significant factor to achieving successful clinical outcomes. This chapter provides a review of the current research on the therapeutic relationship from the perspective of the client – the care recipient. In particular, what do clients find helpful and not helpful as the relationship develops? The authors discuss these factors as they apply across time, countries, and care contexts.