This chapter considers aspects of the relationship between the development and regulation of in vitro fertilization (IVF), pre-implantation genetic testing for monogenic or single-gene disorders (PGT-M, formerly known as pre-implantation genetic diagnosis (PGD)) and mitochondrial replacement techniques (MRTs); critiques of reproductive technologies relating to notions of the “natural”; and women’s interests. It argues that hostility to existing, new and developing technologies increases the difficulties and burdens that women face as they seek to live their working and/or family lives.