This chapter scrutinizes the points at which the two legal regimes intersect with and infuse each other. It provides a brief overview of the international human rights law system, specifically tailored to ground the following parts. The chapter examines the means by which protection is given to the human rights of individuals who are targeted for criminal investigation and prosecution as a result of their alleged involvement in TOC. It briefly explains the means by which the accused’s rights are protected in domestic criminal investigations, and turns to the more complex questions around protecting accused’s rights when they are targeted by interstate cooperation mechanisms such as extradition.