Organized crime is flexible and fluid, with an inbuilt capacity to transcend borders and to change structure and activity. The nodal policing model incorporates the concept of ‘nodal orientation’ and propagates on the one hand a repositioning of police organizations as nodes in a networked security environment, whilst on the other hand it refers to a proactive style of policing focusing on dynamic flows of illegal activities. This chapter discusses the dimensions of the nodal policing strategy by paying attention to how the control of organized crime has become a subject of cooperative policing, both in the sense of multidisciplinary cooperation as well as international policing. It seeks to illustrate how nodal policing has been applied in practice. The chapter discusses the validity of the assumptions that underlie the relatively new policing strategy.