This chapter analyses Italy’s fight against organized and transnational organized crime to see whether any lessons can be learnt. It is quite clear that at an international level, legal instruments need to be updated continuously in order to tackle organized crime, a form of criminality that pays no attention to international boundaries. On 12 December 2019, the Parliament and the Council also approved new regulations on Eurojust. These new rules make the agency more effective in fighting cross-border crime and strengthen cooperation among national authorities in investigation and prosecution of serious cross-border offences. The prosecution can interact with the police both through directives, concerning the investigation plans, and through the delegation of specific activities, including those involving the accused and the counsel for the defence.