Thi s chapter describes research into physics-based real-time simulation from a business perspective and provides guidance for further studies. Despite the increasing amount of research into simulator-driven design and production, little progress has been made toward understanding the complexities of its implementation, its effect on business models, and how it can best be applied to create value for the customer. There seems to be agreement in the literature that this type of digital transformation of industry is beneficial, but many of the business issues remain unclear. The following paragraphs seek to encourage a new way of looking at real-time simulation studies. The chapter concludes with an illustration of sustainable value creation using real-time simulation and digital twinning and a number of concrete suggestions for questions that should be answered in future research.