ABSTRACT
The reasons for noncompliance are diverse and are influenced by a variety of mitigating factors. The impact of therapeutic noncompliance on patient care is immense. Noncompliance has both clinical and economical implications, and there is ample evidence to indicate that noncompliant patients have less effective control of their condition than compliant patients. The patients are overseen by staff specifically trained in the treatment of epilepsy and the high degree of individual patient supervision ensures good compliance. In essence, this compliant population is an ideal pool for the assessment of the relationship between dose and drug concentrations. For many years, hair was considered to be a homogeneous structure until more detailed histology revealed five specific morphological components, the cuticle, the cortex, the medulla, melanin granules, and the cell membrane. In spite of the increase in the reporting of the presence of a wider range of drugs in hair, there is still considerable debate and uncertainty about the exact mechanism of incorporation.
