The decision of TAP was rightly seen as a downgrade of Oporto Airport's position in TAP's network, motivating harsh public reaction from several businessmen and politicians, including the mayors of Oporto and of several municipalities of the Norte Region. Besides the Norte Region, it encompasses large parts of the Centro Region and of Galicia. Summing up, the results of our study indicate that Oporto Airport activity has influenced in a significant way the economic performance of the three areas of the Norte Region. The chapter analyses the impact of Oporto Airport on the economy of the Norte Region between 2000 and 2016, considering different sectors and how this impact was felt in three different areas of the region at different distances from the airport. It provides the evidence that Oporto Airport activity had a significant impact on the economic performance of the Norte Region in the period under analysis.