The criminalisation of same-sex sexual acts for both men and women is widespread across many African nations, as is intolerance of gender and sexuality diverse (GSD) individuals. However, South Africa enacted the earliest constitutional protections against homophobia in the world. Furthermore, the southern region of the African continent more broadly has garnered international attention from a range of international organisations and activists for a stronger trend towards non-discriminatory legislation than the north, west, east or central regions. Against this background, this chapter identifies a number of Southern African transnational contributions to GSD issues of relevance to international and regional organisations, activists and academics. The chapter has a particular focus on GSD education-related contributions.