ABSTRACT

The arteries constitute the target, place, and common denominator of cardiovascular diseases, which are the main cause of death and disability in modern societies. Arterial aging is one of the pathophysiological foundations for these processes, and it occurs according to a trajectory of progressive loss of arterial compliance, which can be accelerated by the exposition to certain environmental or behavioral factors in association with the individual's genetic predisposition.

The accelerated arterial aging trajectory, designated early vascular aging (EVA), is associated with higher risk of death and cardiovascular morbidity, hence the validation and establishment of arterial aging biomarkers is fundamental. Also important is the development, validation, and implementation of effective intervention strategies able to modify the vascular aging trajectories to biologically more favorable ones.

The [email protected] model constitutes a promising non-pharmacological instrument for the promotion and maintenance of vascular health, relying its action on a multidisciplinary and individualized intervention, where components such as the promotion of physical exercise, nutritional adjustment, cognitive stimulation, and therapy adherence are central intervention elements.