Aging is characterized by a gradual loss of physiological functions, being a markedly heterogeneous physiological process. However, the trajectories of functional decline are potentially modifiable and the promotion of a successful aging achievable. One of the most consensually identified ways of promoting a biologically more favorable aging is through physical exercise and a physically active life. Several studies have shown the benefits of regular physical exercise at several levels, such as physiological, functional, social, and in promoting better quality of life and well-being in the older adult. However, taking into account the particularities of this population, namely given the coexistence of comorbidities, it is essential to prescribe adapted exercise plans and monitor their implementation. On the other hand, these plans should be integrated into a broader strategy for promoting active and healthy aging, as advocated in the [email protected] Intervention Model.