This chapter discusses the (ir)responsible organising of systems of production and reproduction through work and care, highlighting the inequalities – pertaining to gender, but also age, class, and ethnicity – in how work and care are valued and distributed. We examine some key inequalities and interrelations in systems of production and reproduction, in terms of gender, age, life phases, work, and care. How work and care are unevenly distributed between genders and in different phases of the life course is a central question for social sustainability and equality. Foregrounding work, care, and work-care boundaries is necessary in (re)organising work(/non-work) life and the interplay of production and reproduction. Responsible organising within and around societies and organisations means engaging with these persistent realities, and inequalities, at both strategic and everyday levels of organising.