This chapter provides an overview of the approach to the STEM Road Map curriculum series. The chapter briefly reviews the research base used to frame the integrated STEM approach, which uses problem- and project-based learning to engage students in authentic learning experiences aligned with national standards including the Next Generation Science Standards, the Common Core State Standards for Mathematics and English Language Arts, and the Framework for 21st Century Learning. The chapter also offers an overview of the five real-world themes around which the STEM Road Map curricular modules are organized: Cause and Effect, Innovation and Progress, The Represented World, Sustainable Systems, and Optimizing the Human Experience.