The objective of the paper is to understand the various determinants of social innovation incidence at the macroeconomic level across countries in Europe. Using a multivariate regression framework, the paper analyses the role of various characteristics from the ecosystem in which social innovations occur. In particular, the paper quantifies the relative importance of several factors, such as educational attainment, ease of doing business index, corruption index, risk preferences, cultural and social norms, to name a few. Methodologically, the paper takes into account the evolution of macroeconomic circumstances, such as the economic crisis of 2008 or general time trend, by collecting a panel data of various indicators from different data sources across countries and over time. As part of robustness checks, the paper uses three different measures of social innovation and includes country fixed effects to account for heterogeneities across countries.