ABSTRACT
This chapter introduces definitions, principles and research methods of implementation science and reviews the definition and scope of implementation science, placing it within the broader enterprise of biomedical research. In addition, common concepts within implementation science are addressed, including hybrid designs that combine studies of clinical effectiveness and implementation outcomes, the role of adaptation to a setting’s context and recipients while maintaining fidelity to both the core components of the clinical intervention and the implementation process, and the critical need to focus on sustainability throughout an implementation effort.
