The devastating effect of war has no limits in space and time, forces some people to migrate and sometimes hits so hard and lasts so long that it shapes the memory and everyday life of future generations. In this context of crisis, interventions for children must be as extensive as possible if they are to be effective and sustainable. The authors go so far as to affirm the need for the world itself to become a huge, reassuring and well-equipped playroom. The potential of a Polyvagal-informed intervention in restoring a feeling of safety and the main challenge of involving caregivers who are themselves affected by circumstances of high stress, uncertainty, and fear are discussed and illustrated through case examples.