Lorries do a variety of work in cities. They keep cities (economically and socially) moving, while also contributing to urban congestion and pollution, traffic injuries and fatalities. Their logistical mobilities are both relational and contingent. As a result, there is an uneasy relationship between lorries – and their (human) drivers – and cities. Artificial intelligence, by way of the automation of the transport system, is one proposed ‘solution’ to the ‘problem’ of freight haulage as currently imagined. This chapter considers the emergence of autonomous lorries as a process of making the ‘safe’ lorry by eliminating, or reducing the role of, the ‘unsafe’ driver.