ABSTRACT
Sickle cell disease (SCD) is one of the major neglected chronic diseases globally with increasing incidence in parts of Western and Central Africa. Individuals with SCD are highly susceptible to infections, especially bacterial infections which are severe and often lead to death. Thus, the management of infections among people with SCD through preventive or curative interventions is imperative. This chapter highlights SCDs, transmission of the disease, clinical manifestations, and strategies for managing infections and fever in individuals with SCDs.
