ABSTRACT
Parameters of 67 Ga kinetics in tumour patients showed a bimodal distribution, as was also the case in patients without tumours. No difference could be demonstrated between kinetic parameters of tumour patients and patients without tumours. In the present of 1 mM adenosine triphosphate, the most effective mediator examined, the final distribution was 17% bound to TF and 62% to HFE, with 16% not protein-bound. The liver uptake, bile excretion, and urinary excretion of the complex were examined in rats. Electrophoresis of urine samples showed a similar distribution to in vitro mixtures of bleomycin and urine. Capacity factors of the ligands on reverse-phase HPLC were used as a measure of Lipophilicity, and to predict protein binding and in vivo distribution of te complexes. Relative image quality comparison showed a slight preference for Tc-99m HMDP. Under the conditions of this study, Tc-99m HMDP image quality is at least comparable to that of Tc-99m MDP.
