The landmark noted by Michel Foucault, in the former quote, relates to the emergence of 'natural history' as a distinctive domain during the 'Scientific Revolution', while the second quote is drawn from an account of the eighteenth-century development of the notion of 'human nature'. The chapter explores a work seminal to the posthumanist perspectives – We Have Never Been Modern – Bruno Latour argues that perceiving and constructing our world in the image of a domain of nature strictly segregated from another for humanity is to misunderstand what is at issue. While a number of other science studies scholars have made important contributions to post-humanist thinking, the work of Andrew Pickering is particularly notable. The historically constructed notion that there is a non-human domain of 'nature' distinct from that of humanity, generally understood as society and/or culture, has become deeply inscribed into both someone and our world.