Faith-based organizations (FBOs) play an important role in the provision of education and health services in sub-Saharan Africa. Many of these organizations are Christian. One prominent illustration is that of the Christian Health Associations which provide healthcare, especially in East and Southern Africa. Another illustration is that of the large networks of schools managed by dioceses and other religious groups in various countries. The chapter is organized into three complementary parts. The first part provides a rapid diagnostic of the extent to which FBOs in Africa reach the poor. This diagnostic is based on both household survey data and qualitative data collection. The second part focuses on the experience of the late Father Joseph Wresinski and his organization, the International Movement ATD Fourth World, in implementing projects with families in extreme poverty. The last part considers the role of faith and spirituality in informing and sustaining a commitment to reach the poorest.