ABSTRACT
This introduction presents an overview of key concepts discussed in the subsequent chapters of this book. The book focuses on the multidrug-resistant properties of microbial biofilms and their characterisation by different omics approaches such as genomics, transcriptomics, proteomics and metabolomics. It explains the mechanism of host–microbial interaction. The book discusses Interspecific interactions of bacterial–bacterial as well as bacterial–fungal mixed-species biofilms and their implications in polymicrobial diseases. It examines the clinical relevance of the biofilm-associated drug resistance. The book focuses on the clinical implication of microbial biofilms, in particular, biofilm-associated infections (BAIs). It discusses the new information on biofilm microbiome derived from novel gene sequencing technologies. Central venous catheters (CVCs) and urinary catheters associated biofilm infections are a common occurrence in hospital settings. Medical device–associated biofilm infections occur when microorganisms adhere to the indwelling or implanted medical prosthesis. The book explains the clinical implications of microbial biofilms.
