ABSTRACT
Most oral infectious diseases such as dental caries, periodontitis and oral candidiasis are caused by oral biofilms of bacteria or fungi. Probiotics, prebiotics and synbiotics can be considered a potential preventive strategy against oral diseases. Prebiotics have a direct effect on microbial growth as they stimulate the growth of beneficial bacteria and suppress the growth of pathogens in the gastrointestinal tract. Animal and in vitro tests are necessary to select effective probiotic strains and subsequently elucidate the mechanisms of the probiotic effect. The biogenics effect is independent of the colonisation and viability of probiotic bacteria. synbiotics in the intestinal tract can be expected to activate both innate immunity and acquired immunity of cell-mediated and humoral immunity. According to the World Health Organization, probiotics are defined as 'live microorganisms when administered in adequate amounts confer a health benefit on the host'. Oral microbial symbiosis that suppresses the overgrowth of pathogens is important for maintaining a healthy oral ecosystem.
