In this chapter, the author presents how the philosophical and epistemological context prevalent during the scientific revolution, predominantly mechanisms associated with a methodology of reductionism, profoundly influenced the initial attitude of biology towards the natural world. It is only after centuries of compiling discoveries, advances, and concomitant changes in biology conceptual frameworks that the initial influence of the scientific revolution has progressively been ameliorated and finally reverted. The author's intention is to present how the study of the biological phenomena, where wholes and parts are intangibles changing according to the level of study, has converged in a coherent holistic point of view. The path toward the recognition of a holistic attitude was concurrent with its own development as a modern science. Biologists were able to rigorously test their conclusions through experimentation, and they gradually expanded experimentation to the study of most kinds of biological phenomena promoting biology as a new, independent, and accepted natural science paired with physics and chemistry.