Skip to main content
Taylor & Francis Group Logo
    Advanced Search

    Click here to search products using title name,author name and keywords.

    • Login
    • Hi, User  
      • Your Account
      • Logout
      Advanced Search

      Click here to search products using title name,author name and keywords.

      Breadcrumbs Section. Click here to navigate to respective pages.

      Chapter

      ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance
      loading

      Chapter

      ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance

      DOI link for ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance

      ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance book

      ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance

      DOI link for ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance

      ΑLpha-Actinin-3’s Role in the Genetic Control of Muscle Strength and Performance book

      ByJane T. Seto, Fleur C. Garton, Kathryn N. North, Peter J. Houweling
      BookRoutledge Handbook of Sport and Exercise Systems Genetics

      Click here to navigate to parent product.

      Edition 1st Edition
      First Published 2019
      Imprint Routledge
      Pages 21
      eBook ISBN 9781315146287
      Share
      Share

      ABSTRACT

      The α-actinin-3 gene (ACTN3) R577X polymorphism is one of the most highly studied genetic variations associated with human skeletal muscle function and performance. This chapter summarizes the current research in ACTN3 R577X and discusses the molecular mechanisms that underlie the consequences of a-actinin-3 deficiency, with new insights into implications for the general population beyond athletic performance — in healthy ageing, muscle disuse, and disease. The α-actinins are a family of four actin-binding proteins that have evolved from repeated gene duplication events to perform similar roles in different cell types. The role of sarcomeric α-actinins in the maintenance of ordered myofibrillar arrays in skeletal muscle make them prime candidate genes for human muscle disease. The varied allele frequencies observed between the different ethnic groups and specialized protein expression in fast glycolytic muscle fibers suggest that selective forces may be acting on the ACTN3 577X allele during modern human evolution.

      T&F logoTaylor & Francis Group logo
      • Policies
        • Privacy Policy
        • Terms & Conditions
        • Cookie Policy
        • Privacy Policy
        • Terms & Conditions
        • Cookie Policy
      • Journals
        • Taylor & Francis Online
        • CogentOA
        • Taylor & Francis Online
        • CogentOA
      • Corporate
        • Taylor & Francis Group
        • Taylor & Francis Group
        • Taylor & Francis Group
        • Taylor & Francis Group
      • Help & Contact
        • Students/Researchers
        • Librarians/Institutions
        • Students/Researchers
        • Librarians/Institutions
      • Connect with us

      Connect with us

      Registered in England & Wales No. 3099067
      5 Howick Place | London | SW1P 1WG © 2022 Informa UK Limited