ABSTRACT
The exact etiology underlying soft tissue injuries remains to be elucidated though they are recognized as complex phenotypes with both intrinsic and extrinsic factors contributing to injury risk. Although there are numerous benefits to participating in regular physical activity, the risk of acute and chronic musculoskeletal soft tissue injuries has risen, with approximately 30-50% of all sporting injuries affecting tendons. This chapter examines the latest findings on the genetic contribution to musculoskeletal soft tissue injuries. Through the application of molecular genetics techniques, aided by molecular and cellular biology techniques, researchers have begun exploring and highlighting functional biological pathways and molecular mechanisms contributing to the pathogenesis of sporting injuries. Genetics research in the field of musculoskeletal soft tissue injuries has followed a candidate gene approach. The primary objective in elucidating the genetic contribution to musculoskeletal soft tissue injuries is to identify the biological pathways and molecular mechanisms contributing to pathogenesis warranting subsequent in-depth exploration.
