This chapter addresses how ethical guidelines and practical training could proactively strengthen the quality of forensic evidence. It also discusses the consequences of bias due to human cognitive and contextual errors that can occur in various stages of forensic evidence management. A modern day hypothetical is provided to illuminate the ethical dilemmas and biases that can easily permeate the investigative process. This chapter seeks to expound on the various ethical dilemmas faced by forensic practitioners as well as the legal ramifications of unattended biases. Pragmatic solutions to the issues created by human cognitive biases are discussed with citations to several research studies that have identified some of the more pervasive sources of human cognitive and contextual bias.