This chapter focuses on the type of electrodermal activity (EDA) measurement and indicator most commonly used in judgment and decision-making (JDM) research—the skin conductance response. It provides an introduction to the use of skin conductance in JDM research with a focus on providing concrete and hands-on advice for the researchers who are unfamiliar with the psychophysiological measure but are interested in using it in their own research. The chapter explores some recommended literature, including the excellent volume by W. Boucsein which gives detailed information about virtually all aspects of EDA. It presents a brief overview of the physiological background of EDA, and examines pragmatic issues concerning its assessment. The chapter outlines some pointers towards the relevant literature and toolboxes so that researchers interested in using these more advanced methods have some starting points to delve into the data analysis approaches.