Since 2000, more than 115 million people came to live in urban areas in Latin America. Migration from rural to urban areas is still a major cause of population growth in cities in the region – by 2050, 90% of Latin Americans will be living in cities. Bus Rapid Transit proposes to offer the same level of service of subway or trams, but using buses. Life in cities is heavily dependent on two spatial characteristics: density and mobility. Density promotes more encounters among people, creates the need for more services (and also more job opportunities), and at the same time density optimizes the provision of services and infrastructures. This chapter highlights that, despite all the major and undeniable problems, Latin America has also implemented quite innovative urban mobility solutions. It discusses some challenges Latin American cities are facing that helps us to understand global mobility challenges in critical and novel ways.