Despite improvement in the understanding of nonsuicidal self-injury (NSSI) over the past decade, development of evidence-based approaches for NSSI prevention remains nascent. Given the ubiquity of NSSI in youth and adolescent populations, this paucity is notable. This chapter provides an overview of key prevention concepts that are relevant to the early intervention and prevention of NSSI. A summary of extant empirical research on NSSI and other areas relevant to NSSI prevention is provided. The authors conclude with a summary of recommendations for applying skill and growth-oriented approaches to NSSI prevention as well as recommendations for advancing research in this area.