The final chapter presents the practical implications arising from consequences of tensions emerging when universities engage with actors in peripheral regions. Recommendations to education/science ministries require ensuring that national policy frameworks do not lead universities to downgrade regional missions, whilst regional policy-makers should pay attention to key university actors who may not be their strategic leaders. The volume concludes by arguing that policy-makers and practitioners should seek to better understand the tensions inherent in collaboration as an antecedent to developing better, more implementable, and ultimately more successful strategies for knowledge-based regional development in economically peripheral regions.