Youth unemployment is at present a crucial issue in the EU policy agenda, as well as in the agenda of other developed and developing countries. The economic crisis, which began in mid-2008, has had severe effects on EU and Eastern Europe labour markets and especially on young people. The key aim of this introductive chapter is to review and present the contributions included in the book, that is the upshot of the EU IRSES project “The political economy of youth unemployment”. It also summarizes the most relevant articles already published by the authors involved in the EU project.