Building on the existing foundation of research, this chapter examines two distinctive case studies, the Nepal earthquake of 25 April 2015 and the mixed migration flows through the Western Balkans between spring 2015 and spring 2016. It assesses whether these extraordinary situations indeed led to an increase in trafficking and exploitation and determines the extent to which counter-trafficking efforts were incorporated into overarching response measures. In both cases, the chapter identifies promising practices and challenges in mainstreaming counter-trafficking measures. The biggest ongoing challenge for protection actors in Nepal is to provide vulnerable populations in the districts with critical protection-related information on human trafficking and exploitation. In some countries along the Western Balkan route, meeting the immediate needs of migrants transiting through their territory proved such a challenge during the peak of the movements that only a partial response to vulnerable groups could be ensured for a number of months.