Matter, mind, and meaning: these three terms are bound inextricably together because the third requires recognition and interpretation by the second, and both of these are necessarily dependent on the first. The universe has no overarching purpose or meaning conferred on it from without or within. It has come over time to contain many emergent purposes and meanings but does not itself have a comprehensive purpose or meaning. This chapter explains how Religion of Nature as a species of religious naturalism can be thought of or conceived. Religion of Nature and other forms of religious naturalism can help to make us not only keenly aware of this inexorable fact but also able positively to affirm it. The chapter analyses the issue of how best to practice religious naturalism in one's own life is a matter to be weighed and considered by each individual in his or her own ways and in light of his or her passions, interests, and strengths.