In this chapter, the authors determine that safeness physiology and compassionate mentality are mutually supportive. Compassion-Focused Therapy (CFT) is not a distinct school of therapy, but more a framework for focusing interventions that span across multiple different therapy traditions and approaches. The particular conditions that CFT aims to foster are those of safeness and compassion. CFT is a trans-diagnostic approach as it is based on a science of the brain, rather than a science of any particular 'pathology' or any particular treatment. An important part of CFT is working with the barriers to compassion, many of which are outlined in the Fears of Compassion Scales. For Gerry, there were particular fears concerning receiving compassion from others. The CFT approach of exploring the threat-based function and emotional meaning in voices, and also talking directly with the voices, is different to traditional Cognitive Behaviour Therapy (CBT) for psychosis, which focuses more on working with the appraisals/interpretations of voices.