This chapter explores the learning across the whole programme of work on the factors affecting the agency and uptake of African interests in global health diplomacy during the agenda-setting phase, policy selection and negotiations, and implementation. It deals with D. Fidler’s three ways in which health is applied in foreign policy, viz: as regression, as remediation, or as revolution. The chapter identifies common and different findings for each thematic area, particularly across the case studies, while the desk reviews were used to triangulate evidence, understand limitations of methods, and interpret findings. It presents the findings of the content analysis on the three case studies, reported within the four focus areas of agenda setting, policy development, policy selection and negotiation, and implementation, and focuses on the thematic categories outlined in the methods. Technology transfer and access to medicines have become prominent issues in the new global agenda. Communication flows appeared to have a key influence on both policy negotiation and implementation.