This chapter discusses a critical and people-centred approach both to and within global health. Planetary health has emerged and with great fanfare as an extension of, or successor to, the field of global health. Planetary health draws upon the coalitions of interest, but has benefited from a particularly concerted push to establish it as a distinctive field and framework for action. Much of global health scholarship aims to develop models – more or less hypothetical – of such optimal interventions, and to identify and evaluate programmes that supposedly ‘work’ and that might lend themselves to replication and scaling. Reflecting both on challenges – in particular, the West African Ebola outbreak – and on emerging remodelings of the field, the chapter looks for a critical and people-centred approach both to and within global health. New global health initiatives have been launched that draw on the popular momentum of human-centred design to spur innovation.