ABSTRACT
Bionanotechnological designs for self-assembling nucleoprotein biostructures suggest that nanoscale devices capable of site specific molecular targeting can be constructed. These tools are uniquely equipped to augment immunohistochemistry or drug targeting techniques where increased sensitivity is required, or where antibodies are unavailable. The system we are developing is a nanotechnological implementation of both molecular biology and chemistry. It uses DNA-methyltransferase-directed covalent addressing of fusion proteins to chemically synthesized DNA scaffolds. It offers a practical approach to the construction of bionanostructures in a wide variety of designs that may make it possible to match cell surface structures in a lock and key fashion.
