The palliative-care nurse has a pivotal role as a team member in the alleviation of nausea and vomiting and associated symptoms. The nurse's role in the management of nausea and vomiting requires excellent assessment skills and contemporary knowledge of physiology, current pharmacology, and appropriate non-pharmacological interventions. The causes of nausea and vomiting can be divided into four categories: chemical; visceral; central nervous system; and vestibular dysfunction. The systematic documentation of the symptoms of nausea and vomiting is the foundation for the adjustment of antiemetic drugs and other therapy to allow optimal control of these distressing symptoms. Measures to reduce nausea and vomiting include planning and presenting meals in accordance with the likes of the person. Percutaneous gastrostomy might be appropriate for persistent nausea and vomiting related to bowel obstruction. Careful analysis of the causes of nausea and vomiting combined with appropriately applied therapeutic intervention can usually improve these symptoms to an acceptable level for the patient.