In this chapter, the CeHRes Roadmap – a framework for eHealth development, implementation and evaluation – is explained. The Roadmap consists of six main phases: the contextual inquiry, value specification, design, operationalization, summative evaluation and formative evaluation. In this chapter, the rationale behind the Roadmap is provided. After that, each phase is explained, its objectives are stated, relevant concepts, methods and activities are explained, and the types of outcomes of the phase are given. Furthermore, cases are provided to illustrate certain abstract concepts, and references to other chapters that provide more in-depth information are included.