In Canada, there are significant gaps and disparities between the health conditions of the urban Indigenous population and those who live on reserves, as well as those of the Canadian population as a whole. Far from being limited to epidemiological or biomedical manifestations, health issues as related to Indigenous people necessarily evoke dimensions that are of a systemic and structural nature, where their legal status, constitutional recognition, capacity toward self-determination, and legitimate role within society are all at stake. The initiatives to curb these inequalities must ensure a real contribution from these peoples in decision-making and the governance of their social and public affairs; these initiatives must propose a real division of powers and be based on a collective, democratic, and global vision of health for the benefit of those directly concerned. These are the founding principles of the Minowé Clinic project established in a small Mid-Northern Québec town by the Val-d’Or Native Friendship Centre.