This chapter explores the intersectional realities of race/ethnicity, sexual orientation, and gender identity for LGBTQIA (lesbian, gay, bisexual, transgender, queer, questioning, intersex, asexual and ally) individuals of color. It presents the current research-based knowledge about LGBTQIA individuals of color; the social work values, ethics, and skills for culturally sensitive practice with this population; and community resources for client support and empowerment. The chapter provides an overview of racial and ethnic identity development theories and LGBTQIA developmental models, multi-culturally sensitive social work practice with LGBTQIA people of color requires a more in-depth exploration of the theories. It discusses the affirmative social work practice and a model for culturally competent practice with LGBTQIA populations. The chapter reviews the basic tenets of stigmatization theory, minority stress theory, and intersectionality. These three theories provide a framework for understanding the impact of living with multiple marginalized identities.