This chapter examines how ICT use can impact well-being outcomes among older adults with both review of the literature and analysis of a 5-year longitudinal study conducted in the Deep South region of the US that investigated the impact of ICT use on quality-of-life outcomes among older adults. It provides a high-level overview of one such attempt to help older adults overcome the digital divide by teaching them how to use computers and the Internet. While significant amounts of research on ICTs have focused on how they can be used to help individuals age in place, the chapter evaluates the research on how ICTs can be used to mitigate negative health outcomes and increase well-being and quality of life. Social isolation is an objective measure in which the number of social relationships available is reduced or limited. This may occur as a result of geographic displacement and removal from former social networks.