This chapter explores the diversity of population groups and geographic contexts implicated in pedestrian injury risk, while considering the role of a mixed-methods approach for so doing. Through its focus on scalar and methodological diversity, we begin by exploring the range of knowledge produced by intersecting qualitative and quantitative approaches to understanding pedestrian injury in Vancouver, Canada. A recent review article identified a range of current methodological approaches in global health geographical inquiry, from quantitative approaches such as spatial analysis and Qualitative Geographic Information (GIS) and multilevel statistical modeling, to qualitative methods including oral history, participatory methods, and narrative analysis. Knowledge of the particular groups at risk of pedestrian injury has been greatly enhanced through geographic analysis by health geographers and public health researchers. Similarly, a study in Los Angeles, California attempted to understand the diverse contexts and populations at risk of pedestrian injury by using both quantitative and qualitative methods, although in a slightly different way.