Regional Smart Specialisation Strategies (S3) aim at developing regional competitive advantages following a vertical1 prioritisation logic (Foray and Goenaga, 2013). Central to this prioritisation is the bottom-up identification of a limited set of priorities where regions believe they have potential to obtain a comparative advantage. Priorities are identified through the interaction of stakeholders across the quadruple helix of government, industry, academia and society at large. This is because entrepreneurial knowledge is most often distributed across a regional system. This cyclical and recursive process of identification and prioritisation is referred to as an entrepreneurial discovery process (EDP).