The discussion of determinism/indeterminism in the natural world is not only a concern for epistemology and philosophy of science; it also has strong implications for natural theology. On the one hand, the distinction between determinism and predictability has led to deeper research into the relationship between ontological and gnoseological realms. On the other hand, the multiple descriptions proposed by contemporary science cannot avoid the question of the cognitive status of the various scientific formulations and the possibility of a coexistence of deterministic and indeterministic views. This chapter presents the methodological proposal of the abandonment of the mental limit which entails a deep renunciation of any form of monism and of the kind of uniqueness that results from resting at an objectification. Methodic-thematic pluralism not only relates the gnoseological to the ontological realms without confusing them, but also paves the way for establishing the cognitive status of the different scientific disciplines avoiding reduction.