In the first century CE, the new religion of Christianity began to spread across the Mediterranean world. Over the next four centuries, theologians, ministers, and eventually councils of the church worked through various theological controversies and issues. One significant problem for the early church was to sort out the proper relationship between Christianity and the classical culture in which large portions of the educated population were raised. It is at this intersection of Christianity and classical culture that the relationship of science and religion had to be worked out.