This chapter provides a conclusion to the book and describes a number of future research issues. Firstly, in regards to the knowledge integration model (knowledge integration firms) discussed theoretically in Chapters 1 and 2, this chapter organizes the main managerial factors (five items) that promote the configurations of new ecosystems through collaborative innovation, and the insights extracted from a number of case studies and existing research. This chapter then presents these five managerial factors wholly assembled as “the knowledge integration model (knowledge integration firm).” Finally, the chapter discusses implications and future research issues.