ABSTRACT
Multi-channel spike train analysis is applied to extract dynamical interactions of firing activity in spontaneously active monolayer neuronal network in cell culture. A pre-conditional correlational analysis is used to determine the conditional probability of firing of these neurons based on the preceding firing of another neuron in the network. Using this pre-conditional interspike interval analysis, we are able to determine the excitation coupling between the firing of neurons in this network and the timing relationship between the firing of spikes in various neurons of the network. The analysis also reveals which neurons in the network are not coupled.
